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College Football Friday Betting Analysis for Sept 5th, 2025

There are four games in college football on Friday so let's take a look at each matchup and see if we can find some advantages.
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James Madison @ Louisville
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NIU @ Maryland
Western Illinois @ Northwestern
Eastern Washington @ Boise State
MATTāS CORNER
š„ James Madison @ Louisville
Louisville (-13.5) Total 55.5
Friday, September 5th, 2025 - 7:00 PM ET
Weather could be a little bit of a factor as scattered thunderstorms are in the forecast which could complicate things especially if there are lightning delays. It's very hard to make assumptions after one week especially when both teams faced FCS opponents. James Madison is an impressive squad that put up 70 points at North Carolina last year. The Dukes defense runs some exotic looks under Colin Hitschler so I wonder if there is a slow start for Louisville. The Cardinals are 8-3 ATS at home as a favorite under Jeff Brohm and should be able to score some points. To me, the lean here is over 4.5 touchdowns for Louisville which is available on Draftkings, but I'm not playing anything officially.

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